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New research -- Vitamin B3 can protect against sun

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Created by Robbo2099 > 9 months ago, 24 Nov 2008
Robbo2099
WA, 738 posts
24 Nov 2008 9:53AM
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For those not versed in reading scientific papers--Here's the English translation of the text in the abstract below:

Taking 500mg daily of vitamin B3 (nicotinamide) appears to be an inexpensive method of reducing your chance of getting skin cancer from overexposure to the sun. Studies show that it protects skin against the the immune system suppression caused by ultraviolet radiation from the sun which in turn is likely to reduce your chance of developing skin cancer. NOTE: It does NOT prevent sunburn but does seem to stimulate your body's ability to preserve your skin's health, despite exposure to sunlight.

This finding may be a very significant finding and could contribute to a major reduction in skin cancers.
___________________________

Nicotinamide (Vitamin B3) Protects Against Ultraviolet Radiation-Induced
Immunosuppression In Humans


Diona Damian, Eleni Yiasemides, Geetha Sivapirabu, Joohong Park, Gary Halliday
University of Sydney, Sydney, NSW, Australia


Nicotinamide, the amide form of vitamin B3, has been shown to prevent UV-induced immunosuppression and carcinogenesis in mice, and is immune protective in humans when applied topically.

Using the Mantoux model of skin immunity in groups of 30 healthy volunteers, we compared oral nicotinamide supplementation to placebo in a randomised, double-blinded cross-over study. Discrete areas of the lower back were irradiated with low-dose solar-simulated UV daily for 3 consecutive days. Mantoux testing with tuberculin purified protein derivative was then performed at both irradiated sites and adjacent unirradiated sites serving as immunologically intact controls.

Immunosuppression was measured as the difference in Mantoux-induced erythema of irradiated test sites compared to unirradiated control sites. Significant UV-induced immunosuppression occurred in a dose dependent manner in the presence of placebo.

Oral nicotinamide (1500mg daily) was well-tolerated and significantly protected against UV-induced immunosuppression with no effect on UV-induced erythema (sunburn) or unirradiated immune responses.

In a second group of volunteers, low dose nicotinamide (500mg daily) conferred similar levels of immune protection. Our previous microarray studies suggested that nicotinamide normalises subsets of apoptosis, energy metabolism and immune function related genes that are down-regulated by UV exposure.

We have now confirmed the microarray findings from selected key genes in these pathways using quantitative real time RT-PCR and found that nicotinamide appears to exert its UV protective effects primarily via its role in cellular energy pathways. Nicotinamide is safe and inexpensive and looks promising as a chemopreventive agent for skin cancer.


allenpress.conference-services.net/viewPDF.asp?abstractID=231937&conferenceID=1196

secure.jbs.elsevierhealth.com/action/cookieAbsent?code=null


555
892 posts
24 Nov 2008 10:01AM
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555
892 posts
24 Nov 2008 11:59AM
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Mr float said...

mate this is Australia .here we eat


tho I'm not sure if niacin (b 3 ) is the bit that the article talks about
it seems it is the amide form (whats that ?)Nicotinamide, the amide form of vitamin B3,



Same here in NZ.. but Marmite has more of the b vitamins in it. Not my first choice at lunchtime.

Still either is probably more effective if applied externally.


There is also anecdotal evidence that the some elements of the b vitamins leach out through your skin and make you less 'tasty' for sandflies and mosquitoes. You have to eat a fair bit though..

tightlines
WA, 3481 posts
24 Nov 2008 12:16PM
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An interesting post and I don't want to take this off topic too far but I thought I would share a bit of trivia.
Vegemites original name was Pawill.....in response to the competions Marmite, well at least thats what the rep from Kraft said in a radio interview.

Ithink i will stick to smearing sunblock and zinc.

getfunky
WA, 4485 posts
24 Nov 2008 12:18PM
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If you drink enough VB you will probably poo vegemite.. and it will still be nicer tasting than marmite!

Your skin will be great but your grey cells will be in short supply.

p train
VIC, 2629 posts
24 Nov 2008 2:44PM
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There is also anecdotal evidence that the some elements of the b vitamins leach out through your skin and make you less 'tasty' for sandflies and mosquitoes. You have to eat a fair bit though..


I was told about this in the Army by a few guys, so I tried it once by taking vit B supplements. It worked but after a few weeks you start to sweat it out, which gets a bit on the nose.

puppetonastring
WA, 3619 posts
25 Nov 2008 8:11AM
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p train said...
but after a few weeks you start to sweat it out, which gets a bit on the nose.


Id rather smell like I'm dead than actually take on the condition

richswing
WA, 724 posts
25 Nov 2008 12:37PM
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The Powers of Vitamin B.

They say that vitamin B17 is so effective against cancers that it would actually put the so called cancer fighting Medical Companies out of business and the funny thing is it is illegal in most 1st World countries including Australia.

I know of someonewho has prostate cancer and the doctors said they would have remove most of his nether regions to the extent that his Johnson would not stand to attention. He started taking B17 and within a month is PSA (I think that is the acronym) level dropped to half, makes you wonder.

But there are other sources for B17, most seeds contain it, Apricot kernals, Apples seeds, etc. B17 is actually that bitter taste of the seed.

So the saying "An Apple a day keeps the Doctor at bay" could be true.
So eat the whole apple and make sure you grind those seeds down to a pulp before swallowing otherwise they will get flushed down the toilet.

Cheers
Rich



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